Evaluating Clinical Literature

Busy practitioners often cannot keep up with the clinical literature regarding medications. Additionally, research studies can be of varying quality and it can be difficult to find time to conduct a thorough evaluation of each study. The purpose of this section is to provide a brief guide to evaluate evidence presented to a practitioner - whether it be through a journal article, continuing medical education, or pharmaceutical representative. Also included is information regarding evaluating medication for off-label use.

Evaluating Research Studies

The spectrum of evidence found in research studies ranges from detailed meta-analyses to personal communication. This section provides information on how to efficiently evaluate the evidence provided in research studies to help make the best treatment decisions for your patients. Click on the pyramid below to review the methods.

Hierarchy of Evidence

The spectrum of evidence ranges from detailed meta-analyses to personal communication. Sackett's Hierarchy of Evidence, pictured below, arranges types of clinical research findings according to complexity while taking into account the experiences of practicing medicine.

For the hierarchy of evidence list:
Sources: Sackett’s Hierarchy of Evidence